Patterns of seroprevalence of feline viruses among domestic cats and Pallas’ cats

Pavlova, E. V., Kirilyuk, V. E., & Naidenko, S. V. (2015). Patterns of seroprevalence of feline viruses among domestic cats (Felis catus) and Pallas’ cats (Otocolobus manul) in Daursky Reserve, Russia. Canadian Journal of Zoology, 93(11), 849-855.

Few data are available on the prevalence of feline viruses in the wild and little is known about natural sources of infections. The aim of this study was to estimate patterns of seroprevalence to feline viruses (feline immunodeficiency virus (FIV), feline calicivirus (FCV), feline panleukopenia virus (FPV), feline herpesvirus (FHV), and feline leukemia virus (FeLV)) in two cat species, domestic cats (Felis catus L., 1758) (n = 61) and Pallas’ cats (Otocolobus manul (Pallas, 1776)) (n = 24), living in the same area, in Daursky Reserve, Russia. Our results indicate that four of five viruses are circulating in the study area, with the exception of FHV. The pattern of FCV and FPV prevalence differed from FIV and FeLV. FCV and FPV seroprevalence did not depend on the sex and predominated in the group of cats living in the village (76% and 55%, respectively). No Pallas’ cats were seropositive to these viruses. The prevalence of FIV and FeLV were similar in areas with different cat densities (at the stations (16% for both viruses) and in the village (16% for both viruses)). The patterns of seroprevalence between species testify to the low rate of interspecific contacts. In Pallas’ cats, we found the presence of antibodies to FIV to be 5% and antigens of FeLV to be 5%, pathogens for which transmission demand close direct contacts between animals (mainly aggressive and (or) sexual contact), which is typical in the breeding season. Arid climate may also reduce patterns of viral prevalence in the study area, decreasing the risk of infection for both cat species.

Pathogen exposure varies widely among sympatric populations of wild and domestic felids

Carver, S., Bevins, S. N., Lappin, M. R., Boydston, E. E., Lyren, L. M., Alldredge, M. W., Logan K.A., Sweanor, L.L., Riley, S.P.D., Klein Serieys, L.E., Fisher, R.N., Vickers,T.W., Boyce, W.M., McBride, R., Cunningham, M.C., Jennings, M., Lewis, J.S., Lunn, T. Crooks, K.R. & VandeWoude, S. (2015). Pathogen exposure varies widely among sympatric populations of wild and domestic felids across the United States. Ecological Applications.
Understanding how landscape, host, and pathogen traits contribute to disease exposure requires systematic evaluations of pathogens within and among host species and geographic regions. The relative importance of these attributes is critical for management of wildlife and mitigating domestic animal and human disease, particularly given rapid ecological changes, such as urbanization. We screened >1,000 samples from sympatric populations of puma (Puma concolor), bobcat (Lynx rufus) and domestic cat (Felis catus) across urban gradients in six sites, representing three regions, in North America for exposure to a representative suite of bacterial, protozoal and viral pathogens (Bartonella sp., Toxoplasma gondii, feline herpesvirus-1, feline panleukopenea virus, feline calicivirus, feline immunodeficiency virus). We evaluated prevalence within each species, and examined host trait and land cover determinants of exposure-providing an unprecedented analysis of factors relating to potential for infections in domesticated and wild felids. Prevalence differed among host species (highest for puma and lowest for domestic cat) and was greater for indirectly transmitted pathogens. Sex was inconsistently predictive of exposure to directly transmitted pathogens only, and age infrequently predictive of both direct and indirectly transmitted pathogens. Determinants of pathogen exposure were widely divergent between the wild felid species. For puma, suburban landuse predicted increased exposure to Bartonella sp. in southern California, and FHV-1 exposure increased near urban edges in Florida. This may suggest inter-specific transmission with domestic cats via flea vectors (California) and direct contact (Florida) around urban boundaries. Bobcats captured near urban areas had increased exposure to T. gondii in Florida, suggesting an urban source of prey. Bobcats captured near urban areas in Colorado and Florida had higher FIV exposure, possibly suggesting increased intra-specific interactions through pile-up of home ranges. Beyond these regional and pathogen specific relationships, proximity to the wildland urban interface did not generally increase the probability of disease exposure in wild or domestic felids, emphasizing the importance of local ecological determinants. Indeed, pathogen exposure was often negatively associated with the wildland urban interface for all felids. Our analyses suggest cross-species pathogen transmission events around this interface may be infrequent, but followed by self-sustaining propagation within the new host species.

Feral cat vaccination and TNR

Fischer, S.M., C.M. Quest, E. J. Dubovi, R. D. Davis, S.J. Tucker, J.A. Friary, P.C. Crawford, T. A. Ricke, & J.K. Levy. (2007) Response of feral cats to vaccination at the time of neutering. Journal of the American Veterinary Medical Association 230 (1): 52-58

Objective—To determine whether administration of inactivated virus or modified-live virus (MLV) vaccines to feral cats at the time of neutering induces protective serum antiviral antibody titers.

Design—Prospective study.

Animals—61 feral cats included in a trap-neuter-return program in Florida.

Procedures—Each cat received vaccines against feline panleukopenia virus (FPV), feline herpes virus (FHV), feline calicivirus (FCV), FeLV, and rabies virus (RV). Immediately on completion of surgery, vaccines that contained inactivated RV and FeLV antigens and either MLV or inactivated FPV, FHV, and FCV antigens were administered. Titers of antiviral antibodies (except those against FeLV) were assessed in serum samples obtained immediately prior to surgery and approximately 10 weeks later.

Results—Prior to vaccination, some of the cats had protective serum antibody titers against FPV (33%), FHV (21%), FCV (64%), and RV (3%). Following vaccination, the overall proportion of cats with protective serum antiviral antibody titers increased (FPV [90%], FHV [56%], FCV [93%], and RV [98%]). With the exception of the FHV vaccine, there were no differences in the proportions of cats protected with inactivated virus versus MLV vaccines.

Conclusions and Clinical Relevance—Results suggest that exposure to FPV, FHV, and FCV is common among feral cats and that a high proportion of cats are susceptible to RV infection. Feral cats appeared to have an excellent immune response following vaccination at the time of neutering. Incorporation of vaccination into trap-neuter-return programs is likely to protect the health of individual cats and possibly reduce the disease burden in the community.